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Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging

NCT00401336 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 250

Last updated 2023-05-24

No results posted yet for this study

Summary

Iron excess is increasingly regarded as an important cofactor in the morbidity attributed to many disorders. Assessment of body iron stores by measurement of serum ferritin concentrations has poor specificity and the most reliable method is histological or biochemical assessment from a liver biopsy. Because liver biopsy is an invasive procedure, imaging methods have been developed to detect and quantify hepatic iron content. The aim of the study is to use a simplified magnetic resonance imaging (MRI) technique to quantify simultaneously iron and fat contents in the liver and to compare the results to the quantification obtained biochemically.

Conditions

  • Iron Overload
  • Metabolic Syndrome X
  • Hepatitis B
  • Hepatitis C
  • Alcohol Abuse

Interventions

DEVICE

Magnetic resonance imaging multiecho gradient-echo sequence

Breath-hold gradient echo sequences with a single echo and a new multiple-echo gradient-echo sequence

Sponsors & Collaborators

  • Ministry of Health, France

    collaborator OTHER_GOV

  • Rennes University Hospital

    lead OTHER

Principal Investigators

  • Yves Gandon, MD · Rennes University Hospital

  • Eric Bellissant, MD, PhD · Rennes University Hospital

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-11-30
Primary Completion
2013-03-31
Completion
2013-03-31

Countries

  • France
  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00401336 on ClinicalTrials.gov