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Non-invasive Quantification of Liver Iron With MRI

NCT01516853 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2019-12-06

No results posted yet for this study

Summary

The purpose of this study is to validate magnetic resonance imaging as a biomarker of hepatic iron concentration (HIC). Excessive accumulation of iron in the body is highly toxic, specifically in the liver. Accurate, non-invasive assessment of HIC is needed for diagnosis, quantitative staging and treatment monitoring or hepatic iron overload.

Conditions

  • Iron Overload
  • Hemosiderosis

Interventions

DEVICE

Non-contrast MRI

Non-contrast MRI will be performed on each subject, at both 1.5T and 3.0T. Different MRI sequences (spin-echo and gradient-echo) will be used, with varying acquisition parameters (e.g., echo times, spatial resolution).

Sponsors & Collaborators

  • University of Wisconsin, Madison

    lead OTHER

Principal Investigators

  • Scott B Reeder, MD, PhD · University of Wisconsin, Madison

Eligibility

Min Age
10 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2015-06-30
Completion
2015-06-30
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01516853 on ClinicalTrials.gov