MedTrace Logo

Effects of Ketone Bodies on Cognition in Type 2 Diabetes

NCT03657537 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2019-02-20

No results posted yet for this study

Summary

Diabetes negatively affects cognition and increases the risk of developing overt dementia. Decreased cerebral glucose metabolism may be contributing to this effect, thus providing a glucose substitute using ketone bodies might improve neuronal function.

In this study the investigators propose to provide quantitative results on cognitive performance during acute hyperketonemia in patients with type 2 diabetes.

Conditions

  • Type2 Diabetes
  • Ketonemia
  • Cognitive Change

Interventions

DRUG

Ketone infusion

β-hydroxybutyrate is infused intravenously.

DRUG

Saline infusion

saline is infused intravenously.

Sponsors & Collaborators

  • Psychiatric Centre Rigshospitalet

    collaborator OTHER

  • Bispebjerg Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
35 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-17
Primary Completion
2019-02-14
Completion
2019-02-14

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03657537 on ClinicalTrials.gov