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CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease)

NCT04748861 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2025-10-02

No results posted yet for this study

Summary

The overall goal of the CYCLE-AD trial is to determine the role of long-term, high intensity exercise in slowing or delaying the onset of cognitive and AD-related brain changes in e4 carriers. Successful translation and demonstration of the effectiveness of a scalable home-based exercise intervention capable of slowing or delaying disease onset will transform AD treatment, improve patient outcomes and quality of life, and reduce health care costs.

Conditions

  • High Intensity Exercise
  • Normal Cognition
  • Exercise Intervention

Interventions

OTHER

Indoor Cycling (IC)

Participants will ride a Peloton bike 3x/week for 18 months.

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • University of Maryland, College Park

    collaborator OTHER

  • National Institute on Aging (NIA)

    collaborator NIH

  • The Cleveland Clinic

    lead OTHER

Principal Investigators

  • Stephen Rao, PhD · The Cleveland Clinic

  • Jay Alberts, PhD · The Cleveland Clinic

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-20
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04748861 on ClinicalTrials.gov