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The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial

NCT03313895 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 146

Last updated 2025-04-25

No results posted yet for this study

Summary

This multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease \[AD\] signature cortical thickness, and default mode network \[DMN\]) in older adults with amnestic MCI (aMCI).

Conditions

Interventions

BEHAVIORAL

Aerobic & Cognitive Training (ACT)

ACT stands for combined aerobic exercise and cognitive training.

BEHAVIORAL

Cycling Only

Cycling on a recumbent stationary cycle

BEHAVIORAL

Cognitive Training Only

Engage in cognitive training on a computer

BEHAVIORAL

Stretching and Mental Stimulating Activities

Stretching exercises and mental stimulating activities on a computer

Sponsors & Collaborators

  • University of Rochester

    collaborator OTHER

  • Mayo Clinic

    collaborator OTHER

  • University of St Thomas

    collaborator UNKNOWN

  • University of Minnesota

    collaborator OTHER

  • Arizona State University

    lead OTHER

Principal Investigators

  • Fang Yu, PhD · Arizona State University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-05
Primary Completion
2024-07-17
Completion
2024-07-17

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03313895 on ClinicalTrials.gov