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Dementia Risk and Dynamic Response to Exercise

NCT04009629 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 61

Last updated 2022-05-03

Study results available
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Summary

Research suggests that physical exercise supports brain health and cognition as we age. The goal of this project is to examine the specific changes in brain blood flow and biological factors in the blood immediately after exercise in older adults who have the APOE4 gene, a genetic risk factor for developing Alzheimer's. Results from this study will help researchers and clinicians understand and measure changes in the body and brain as a function of exercise, and how those changes relate to Alzheimer's risk.

Conditions

  • Alzheimer Disease 2 Due to Apoe4 Isoform
  • Healthy Aging

Interventions

BEHAVIORAL

Moderate Intensity Aerobic Exercise

Participants will exercise for 15 minutes in a moderate age-predicted heart rate range. The study team will employ an exercise device such as a treadmill, cycle, or recumbent stepper to maintain control over workload.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • University of Kansas Medical Center

    lead OTHER

Principal Investigators

  • Eric D Vidoni, PT, PHD · University of Kansas Medical Center

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-25
Primary Completion
2021-10-28
Completion
2021-10-28

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04009629 on ClinicalTrials.gov