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Ketones for Pulmonary Hypertension - Effects on Hemodynamics

NCT04615754 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2021-12-02

No results posted yet for this study

Summary

In the present study, patients with idiopathic pulmonary hypertension (IPAH) and chronic thromboembolic pulmonary hypertenion will be investigated in a randomized cross-over design with ketone infusions and placebo. Invasive and non-invasive hemodynamics will be evaluated

Conditions

  • Pulmonary Hypertension
  • Ketonemia

Interventions

DIETARY_SUPPLEMENT

Hyperketonemia - use of ketone (3-OHB) infusion

The effect of intravenous ketone supplement

DIETARY_SUPPLEMENT

Placebo - use of saline infusion

Saline is infused as an comparator

Sponsors & Collaborators

  • Danish Heart Foundation

    collaborator OTHER

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Roni R Nielsen, MD PhD · Dept. of Cardiology, Aarhus University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-18
Primary Completion
2021-05-01
Completion
2021-11-29

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04615754 on ClinicalTrials.gov