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Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression

NCT04608981 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2020-10-30

No results posted yet for this study

Summary

To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on:

* Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis.
* Pulpal IL-8 expression.
* Incidence of post-endodontic pain in patients with symptomatic irreversible pulpitis.

Conditions

  • Symptomatic Irreversible Pulpitis

Interventions

DRUG

Prednisolone 30 mg

Steroidal anti-inflammatory drug as a preoperative medication

DRUG

Diclofenac Potassium 50mg Tab

Non-steroidal anti-inflammatory drug as a preoperative medication

DRUG

Placebo

Starch

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Ahmed A Soliman, MSc · Cairo University

  • Khaled Ezzat, PhD · Cairo University

  • Sara S Abouelenien, PhD · Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-31
Primary Completion
2021-12-31
Completion
2022-02-28

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04608981 on ClinicalTrials.gov