Impact of Coronary CT Angiography, Physiologic Assessment and Pharmacotherapy on the Clinical Outcomes

Summary

The investigators aim to investigate the prognostic implication of stenosis and plaque features on coronary CT angiography (CCTA), physiologic assessment, and pharmacotherapy after invasive coronary angiography.

Conditions

• Coronary Artery Disease

Interventions

DIAGNOSTIC_TEST

Fractional flow reserve, Coronary CT angiography

1. Coronary CT angiography (CCTA) and measurement of fractional flow reserve (FFR) will be performed as part of routine clinical practice. The decision to perform CCTA before invasive angiography was at the judgment of the physicians in charge. 2. Physiologic assessment includes delta FFR (lesion-specific) and FFR (vessel-specific) measurement. Delta FFR is defined as a pressure step up across the lesion. Coronary angiography and physiologic assessment will be analyzed by an independent core laboratory (Seoul National University Hospital, Clinical Trial Center, Seoul, South Korea). 3. Stenosis and plaque features on CCTA will be analyzed by an independent CCTA core laboratory (Severance Cardiovascular Hospital, Seoul, Korea), and pericoronary and epicardial fat metrics (fat attenuation index, epicardial fat attenuation index, epicardial fat volume, etc.) will be obtained by an independent cardiac CT fat core laboratory (Tsuchiura Kyodo general hospital, Ibaraki, Japan).

Sponsors & Collaborators

• Seoul National University Bundang Hospital

  collaborator OTHER

• Keimyung University Dongsan Medical Center

  collaborator OTHER

• Ulsan Hospital

  collaborator UNKNOWN

• Inje University

  collaborator OTHER

• Sejong General Hospital

  collaborator OTHER

• Chosun University Hospital

  collaborator OTHER

• Gachon University Gil Medical Center

  collaborator OTHER

• Dong-A University Hospital

  collaborator OTHER

• Wonju Severance Christian Hospital

  collaborator OTHER

• Incheon St.Mary's Hospital

  collaborator OTHER

• Tsuchiura Kyodo General Hospital

  collaborator OTHER

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  collaborator OTHER

• Dong-A ST Co., Ltd.

  collaborator INDUSTRY

• Seoul National University Hospital

  lead OTHER

Principal Investigators

• Bon-Kwon Koo, MD, PhD · Seoul National University Hospital

Eligibility

Min Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-08-12

Primary Completion

2024-12-31

Completion

2025-12-31

Countries

• South Korea

Study Locations