Angiography-Derived FFR And IVUS for Clinical Outcomes in Patients With Coronary Artery Disease

Summary

Comparison of Angiography-derived Fractional FLow Reserve And IntraVascular Ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with CoRonary Artery Disease

Conditions

• Coronary Artery Disease

Interventions

PROCEDURE

Angiography-derived FFR

The percutaneous coronary intervention using drug-eluting stent will be indicated according to following criteria in the Angiography-derived FFR-guided strategy arm \*Criteria for revascularization: Angiography-derived FFR ≤ 0.80

PROCEDURE

IVUS

The percutaneous coronary intervention using drug-eluting stent will be indicated according to following criteria in the IVUS-guided strategy arm \*Criteria for revascularization: Minimum lumen area (MLA) ≤ 3mm2 or 3\< MLA ≤ 4mm2 \& Plaque burden \> 70%

Sponsors & Collaborators

• Seoul National University Hospital

  collaborator OTHER

• Affiliated Hangzhou First People's Hospital

  collaborator UNKNOWN

• Wuhan University

  collaborator OTHER

• Peking University Third Hospital

  collaborator OTHER

• The Affiliated Hospital of Hangzhou Normal University

  collaborator OTHER

• RenJi Hospital

  collaborator OTHER

• Second Hospital of Shanxi Medical University

  collaborator OTHER

• First Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Second Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Changxing People's Hospital

  collaborator OTHER

• The Affiliated Hospital of Medical College, Ningbo University

  collaborator OTHER

• Jinhua Central Hospital

  collaborator OTHER

• Shandong University of Traditional Chinese Medicine

  collaborator OTHER

• Dongyang People's Hospital

  collaborator OTHER

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• Jining First People's Hospital

  collaborator OTHER

• Second Affiliated Hospital of Shantou University Medical College

  collaborator OTHER

• Ulsan University Hospital

  collaborator OTHER

• Huizhou Municipal Central Hospital

  collaborator OTHER

• Zhejiang Greentown Cardiovascular Hospital

  collaborator OTHER

• The Fourth People's Hospital of Jinan

  collaborator UNKNOWN

• First Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  lead OTHER

Principal Investigators

• Jian'an Wang, MD, PhD · Second Affiliated Hospital, School of Medicine, Zhejiang University

• Bon-Kwon Koo, MD, PhD · Seoul National University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-05-29

Primary Completion

2024-09-30

Completion

2028-09-30

Countries

• China
• South Korea

Study Locations