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Quantitative Fractional Ratio-guided Revascularization in STEMI Patients With Multi-vessel Disease

NCT04259853 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1016

Last updated 2022-08-01

No results posted yet for this study

Summary

About half of patients with ST-segment elevation myocardial infarction (STEMI) have multi-vessel lesions (\> 50% diameter stenosis). But how to deal with the non-culprit vessels is still controversial. Previous studies have shown that flow fractional reserve (FFR)-guided revascularization on non-culprit vessels can further improve prognosis of such patients. However, FFR requires the use of pressure guidewire and special drugs such as adenosine to maximize induction of hyperemia forcoronary artery, which will increase the cost of operation and may cause additional risks. Quantitative flow ratio (QFR) is a novel angiography-based method for deriving FFR without pressure wire or induction of hyperemia. In present, there still are poor data about QFR-guided revascularization on non-culprit vessels in patients with STEMI. The purpose of this study is to compare the clinical effects of QFR-guided with angiography-guided revascularization on non-culprit vessel in STEMI patients with multi-vessel lesions.

Conditions

  • ST Elevation Myocardial Infarction
  • Multi-Vessel Coronary Artery Stenosis

Interventions

PROCEDURE

PCI

Revascularization on non culprit vessel

Sponsors & Collaborators

  • Pulse Medical Imaging Technology (Shanghai) Co., Ltd

    collaborator INDUSTRY

  • Fujian Medical University

    lead OTHER

Principal Investigators

  • Lianglong Chen, MD, PhD · Fujian Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-30
Primary Completion
2024-01-30
Completion
2026-02-28

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04259853 on ClinicalTrials.gov