International Collaboration of Comprehensive Physiologic Assessment

Summary

The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).

Conditions

• Stable Angina
• Unstable Angina
• Non-ST Elevation Myocardial Infarction
• ST-segment Elevation Myocardial Infarction

Interventions

DIAGNOSTIC_TEST

Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance

The pressure sensor was positioned at the distal segment of a target vessel, and intracoronary nitrate was administered before each physiologic measurement. To derive resting mean transit time (Tmn), a thermodilution curve was obtained by using 3 injections (3-4 mL each) of room-temperature saline. Hyperemic proximal aortic pressure (Pa), distal arterial pressure (Pd), and hyperemic Tmn were measured during sustained hyperemia. CFR was calculated as resting Tmn/hyperemic Tmn. FFR was calculated as the lowest average of 3 consecutive beats during hyperemia. The uncorrected IMR was calculated by Pd × Tmn during hyperaemia. All IMR values were corrected by Yong's formula (Pa × Tmn × (\[1.35 × Pd/Pa\] - 0.32).

Sponsors & Collaborators

• Samsung Medical Center

  collaborator OTHER

• Tsuchiura Kyodo General Hospital

  collaborator OTHER

• Hospital San Carlos, Madrid

  collaborator OTHER

• Imperial College Healthcare NHS Trust

  collaborator OTHER

• Tokyo Medical and Dental University

  collaborator OTHER

• Sungkyunkwan University

  collaborator OTHER

• Inje University

  collaborator OTHER

• Keimyung University Dongsan Medical Center

  collaborator OTHER

• Ulsan University Hospital

  collaborator OTHER

• Seoul National University Hospital

  lead OTHER

Principal Investigators

• Bon-Kwon Koo, MD, PhD · Seoul National University Hospital

• Javier Escaned, MD, PhD · Hospital Clinico San Carlos, Madrid, Spain

• Tsunekazu Kakuta, MD, PhD · Tokyo Medical and Dental University, Tokyo, Japan

• Joo Myung Lee, MD, MPH, PhD · Samsung Medical Center, Seoul, Korea

Eligibility

Sex

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-06-01

Primary Completion

2018-06-01

Completion

2018-09-26

Countries

• Japan
• South Korea
• Spain

Study Locations