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Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery

NCT04523909 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2023-03-31

No results posted yet for this study

Summary

Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.

The aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium.

Patient undergoing thoracic aortic surgery will have an external lumbar drain (ELD) in situ on the day before surgery. This ELD remains in place during and three days after surgery to reduce the risk on periprocedural spinal cord ischemia. Paired measurements of CSF and blood will be analyzed.

Conditions

  • Postoperative Delirium
  • Postoperative Cognitive Dysfunction
  • Thoracic Aortic Aneurysm

Interventions

DIAGNOSTIC_TEST

Trajectory of neuroinflammatory proteins in CSF and blood

Kinetics of neuroinflammatory markers in CSF and blood

Sponsors & Collaborators

  • Radboud University Medical Center

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-12-18
Primary Completion
2025-12-01
Completion
2026-12-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04523909 on ClinicalTrials.gov