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Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care

NCT01993836 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 191

Last updated 2023-03-22

Study results available
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Summary

This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF), and/or changes in brain connectivity. The investigators will also examine whether different types of anesthesia have different effects on these CSF markers of Alzheimers disease, or different effects on thinking and memory after anesthesia and surgery, or differential effects on the correlation between cognitive changes and CSF marker changes.

Conditions

  • Alzheimers Disease
  • Postoperative Delirium
  • Post Operative Cognitive Dysfunction

Interventions

DRUG

Total intravenous anesthesia with propofol

DRUG

General anesthesia with isoflurane

Sponsors & Collaborators

Principal Investigators

  • Miles Berger, MD, PhD · Duke University Medical Center, Anesthesiology Department, Neuroanesthesia Division

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-11-30
Primary Completion
2019-01-10
Completion
2019-01-10

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01993836 on ClinicalTrials.gov