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Cognitive Fraility and Biomarkers in Older Patients

NCT07184073 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 129

Last updated 2025-09-19

No results posted yet for this study

Summary

this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery.

The main questions it aims to answer is:

* Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions?
* Can these biomarkers be used as potential tools for early identification in vulnarable populations?

Conditions

Interventions

BEHAVIORAL

assessment Mini mental state examination

pre operatively four weeks postoperatively

BEHAVIORAL

assessment FRAIL scale

pre operatively four weeks postoperatively

OTHER

collecting cerebrospinal fluid during regional anesthesia

In the operating room regional anesthesia was administered according to the surgical plan

Sponsors & Collaborators

  • Baskent University

    lead OTHER

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-03
Primary Completion
2022-09-04
Completion
2022-09-04

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07184073 on ClinicalTrials.gov