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Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery

NCT04679259 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2026-01-20

No results posted yet for this study

Summary

Delayed neurocognitive recovery is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine racemase in blood as an indicator of delayed neurocognitive recovery after cardiac surgery.

Conditions

  • Postoperative Cognitive Dysfunction

Interventions

DIAGNOSTIC_TEST

Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood

Blood sampling is done before surgery and at 1, 2, and 7 day after surgery. The level of D-Amino Acid Oxidase, D-serine and Serine in blood are assessed.

DIAGNOSTIC_TEST

Neurocognitive test

Neurocognitive test is performed before surgery and at 7 day after surgery

DIAGNOSTIC_TEST

Assessment of delirium

Postoperative delirium is assessed daily during 7 days after surgery.

Sponsors & Collaborators

  • SMG-SNU Boramae Medical Center

    lead OTHER

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-06
Primary Completion
2025-10-22
Completion
2025-10-29

Countries

  • South Korea

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04679259 on ClinicalTrials.gov