MedTrace Logo

Advanced Translational Research on Childhood Leukemia

NCT04478006 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2026-02-03

No results posted yet for this study

Summary

Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of \<50%, which is unlikely to be boosted by intensification of standard chemotherapy due to overwhelming toxicity. The advent of effective and safe targeted therapies for high-risk cases is therefore imperative. This study constitutes two research projects aiming at driving therapeutic advances.

Conditions

  • Childhood Leukemia

Interventions

GENETIC

RNA-seq

Gene expression and fusion transcripts analysis

GENETIC

whole exon sequencing

Genetic alternation analysis

OTHER

Cytogenetics test

Remission and relapse are monitored by cytogenetic analyses.

Sponsors & Collaborators

  • Chinese University of Hong Kong

    lead OTHER

Principal Investigators

  • Kam Tong Leung, Ph. D. · Chinese University of Hong Kong

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-07-01
Primary Completion
2028-06-01
Completion
2028-06-01

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04478006 on ClinicalTrials.gov