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Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

NCT04449510 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2025-07-15

No results posted yet for this study

Summary

This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21). The specific aim is to determine the impact of e-cigarette pH levels on nicotine pharmacology, systemic exposure to toxic volatile organic compounds (VOCs), and short-term cardiovascular effects.

Conditions

  • Cardiovascular Risk Factor
  • Nicotine Dependence

Interventions

OTHER

Electronic Cigarette

E-cigarette Device: The delivery device will be a variable wattage all-in-one device with operating wattage of 7.0 - 75.0 W. The device will be set at 10 watts for the study visits.

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • Food and Drug Administration (FDA)

    collaborator FED

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of California, San Francisco

    lead OTHER

Principal Investigators

  • Gideon St. Helen, PhD · University of California, San Francisco

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-04
Primary Completion
2024-07-31
Completion
2024-07-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04449510 on ClinicalTrials.gov