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Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)

NCT04439994 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2023-10-03

No results posted yet for this study

Summary

In this experiment, the investigators would like to test the following:

1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ?
2. Can these canges correlate with the development of local hyperalgesia?
3. How does the plasma miRNA expression change over a duration of 24 hours post pain induction ?
4. Which mRNA targets are potentially affected by acute pain?

Conditions

  • Hypertonic Saline
  • Isotonic Saline

Interventions

OTHER

hypertonic saline

The participant will be given i.d. in 0.1 mL volumes of a hypertonic saline solution

OTHER

Saline injection

The participant will be given i.d. in 0.1 mL volumes of a saline solution

PROCEDURE

Blood sampling

Whole blood samples (5 mL per each time point, a total of 20 mL per subject) will be collected

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-01
Primary Completion
2021-07-01
Completion
2022-07-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04439994 on ClinicalTrials.gov