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A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

NCT05856136 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 69

Last updated 2026-02-27

No results posted yet for this study

Summary

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Conditions

  • Respiratory Function Loss
  • Respiratory Complication

Interventions

DRUG

Fentanyl Injection

Three different fentanyl doses (used for sedation) will be evaluated on their effects on shear wave elastography (SWE) and breathing

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Mayo Clinic

    lead OTHER

Principal Investigators

  • Carlos Mantilla, MD, PhD · Mayo Clinic

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-19
Primary Completion
2025-12-08
Completion
2026-06-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05856136 on ClinicalTrials.gov