Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis

Summary

Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing pain and cartilage degeneration and improving muscle strength, joint biomechanics and physical functioning. But, research shows that co supplementation can further augment the effects of resistance exercise. However, it is imperative to point out that the existing evidence is majorly focused on the individual effects of resistance exercise training and non-pharmacological supplementation, and is still deficient in the effects of co-supplementation in addition to resistance exercise training in patients with knee osteoarthritis.

Conditions

• Knee Osteoarthritis

Interventions

OTHER

Lower Extremity Resistance Exercise Training

3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press (8-12 RM) leg extension (8-12 RM) Sit to stand squat (with weight) Stationary Cycling (Maximum Resistance as per patient tolerance till failure)

OTHER

Home Exercise Plan

2 sets of 10 repetitions/day of 1. AROM isolated knee extension and knee flexion 2. Isometric isolated knee extension and knee flexion 3. Isometric terminal knee extension 4. Sit to stand squat terminal extension as Home Exercise Program (HEP). (Iwamoto J et al, 2007)

DEVICE

Electrotherapy + Heating

Iinterferential Current therapy (2P), in combination with heating pad for 20 minutes

PROCEDURE

Joint Mobilization

1. Tibio-femoral Anterior Glide 2. Tibio-femoral Posterior Glide 3. Patellofemoral Joint Mobilization

DIETARY_SUPPLEMENT

Creatine Supplementation

Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks

DIETARY_SUPPLEMENT

Glucoseamine/ Chondritin Sulfate Supplementation

Glucoseamine/ Chondritin Sulfate Supplementation (500mg+400mg/day)

Sponsors & Collaborators

• Isra University

  collaborator OTHER

• Foundation University Islamabad

  lead OTHER

Principal Investigators

• Muhammad Osama, PhD* · Foundation University Institute of Rehabilitation Sciences

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-01-01

Primary Completion

2020-11-30

Completion

2020-12-31

Countries

• Pakistan

Study Locations