An Evaluation of the Graded Weight-bearing Exercise in Patients With Knee Osteoarthritis.

Summary

Background: Knee osteoarthritis is the most common disorder impacting the synovial joint. The prevalence of osteoarthritis rises with age, and its consequences on health and socioeconomic are significant, which emphasize the need for clinical and cost-effective treatments for patients with knee OA. Knee OA is a widespread joint arthritis disease combined with many clinical features such as pain, decreased joint proprioception and might lead to loss of function and disability.

Aim: To evaluate the effect of a 6-weeks supervised graded weight-bearing exercise program on pain, function, proprioception, muscle strength in patients with knee osteoarthritis.

Material and Method: Thirty-six patients with chronic knee osteoarthritis with age ranging 40-60 years will be recruited from the physical therapy department and randomized into three groups. Group I: will receive graded weight-bearing exercise using the anti-gravity treadmill combined with open kinetic chain exercises. Group II will receive closed kinetic chain exercises with open kinetic chain exercises while group III will receive open kinetic chain exercises only i.e: stretching and strengthening exercises. The outcome measures will be pain, function, proprioception, and muscle strength.

Statistical analysis: To detect changes in the dependent variables within and between groups, one-way repeated measures Multivariate analysis will be applied. If there is a significant change within groups or between tests, the post hoc Bonferroni test will be used to detect the significance between each group and/or each level of measurement. The level of significance is p\<0.05 and confidence interval CI 95%.

Study Design: Single-blinded, randomised control trial.

Conditions

• Knee Osteoarthritis

Interventions

DEVICE

anti-gravity treadmill

participants will perform exercises with partial weight-bearing by using an anti-gravity treadmill

OTHER

Weight-bearing exercises for knee flexors and extensors

Stretching and strengthening exercises will be performed in a weight-bearing position

OTHER

Non weight-bearing exercises for knee flexors and extensors

Stretching and strengthening exercises will be performed in a non-weight-bearing position

Sponsors & Collaborators

• Umm Al-Qura University

  collaborator OTHER

• Imam Abdulrahman Bin Faisal University

  lead OTHER

Principal Investigators

• Ammar S Fadil, Ph.D · Imam Abdulrahman Bin Faisal University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

SEQUENTIAL

Eligibility

Min Age

40 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-12-25

Primary Completion

2023-03-28

Completion

2023-07-10

Countries

• Saudi Arabia

Study Locations