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Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction

NCT04406584 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2023-03-13

No results posted yet for this study

Summary

This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PrP) in the treatment of olfactory dysfunction. PrP can be isolated from a patient's own blood and has been found in previous studies to have anti-inflammatory and pro-regenerative properties. It has been used across multiple specialties, such as Orthopedics, Facial Plastics, Dermatology, Neurology in injected form to treat a wide variety of tissues to encourage the body's inherent regenerative capacity. The investigators have completed a pilot study here evaluating it's use in olfactory loss which demonstrated safety and also suggested efficacy. Therefore, the investigators aim to assess the ability of PrP to improve olfactory function in patients with decreased sense of smell.

Conditions

  • Olfactory Disorder
  • Olfaction Disorders
  • Olfactory Nerve Injuries
  • Olfactory Nerve Disorder
  • Olfactory Nerve Diseases
  • Covid19
  • Post-Viral Disorder

Interventions

PROCEDURE

Injection into olfactory cleft

Already stated above.

Sponsors & Collaborators

Principal Investigators

  • Zara M. Patel, MD · Stanford University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-22
Primary Completion
2022-05-12
Completion
2022-08-11

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04406584 on ClinicalTrials.gov