Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
NCT06482138 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 240
Last updated 2026-05-06
Summary
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.
Conditions
- Covid19
- Olfactory Dysfunction
Interventions
- PROCEDURE
-
Biopsy and Cytobrush
Collection of olfactory cleft biopsies and cytobrushes
Sponsors & Collaborators
-
University Hospital, Geneva
collaborator OTHER -
Max Planck Research Unit for Neurogenetics
collaborator UNKNOWN -
University Hospital Carl Gustav Carus
collaborator OTHER -
University of Zurich
collaborator OTHER -
Universitaire Ziekenhuizen KU Leuven
lead OTHER
Principal Investigators
-
Laura van Gerven · UZ/KU Leuven
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-01-24
- Primary Completion
- 2026-12-31
- Completion
- 2026-12-31
Countries
- Belgium
- Germany
- Switzerland
Study Locations
More Related Trials
-
Characteristics of the Anosmic Olfactory Mucosa
NCT05562050 ·Status: ACTIVE_NOT_RECRUITING
-
Anosmia and Covid-19
NCT05246059 ·Status: COMPLETED ·Phase: NA
-
Prospective Registery of Smell/Taste Clinic Ear/Nose/Throat
NCT06456008 ·Status: RECRUITING
-
Olfactory Cleft Stenosis and Obstruction on Paranasal Sinus CT Scan in Pre Septo Rhinoplasty Patients Without Respiratory Mucosa Pathology : Normal Variants or Pathologic Findings ?
NCT06082193 ·Status: RECRUITING
-
Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19
NCT05226546 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)
NCT04374474 ·Status: WITHDRAWN ·Phase: PHASE4
-
Administration of Systemic Corticosteroids and the Recovery of Gustatory Functions in Patients With COVID-19
NCT05148832 ·Status: COMPLETED ·Phase: NA
-
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
NCT05855369 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
"Platelet Rich Plasma for the Management of Post-Viral Olfactory Dysfunction.
NCT05666492 ·Status: UNKNOWN ·Phase: NA
-
Stellate Ganglion Block for COVID-19-Induced Olfactory Dysfunction
NCT05445921 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
NCT06776042 ·Status: RECRUITING ·Phase: NA
-
Clinical Treatment Research of COVID-19-related Olfactory Dysfunction
NCT05421195 ·Status: UNKNOWN ·Phase: NA
-
Stellate Ganglion Block with Lidocaine for the Treatment of COVID-19-Induced Parosmia
NCT06055270 ·Status: RECRUITING ·Phase: PHASE3
-
COVID-19 Anosmia Study
NCT04495816 ·Status: COMPLETED ·Phase: PHASE2
-
The Nasal Microbiome and Its Importance in Disease
NCT05061329 ·Status: RECRUITING
-
Olfactory Dysfunction of Rhinosinusitis
NCT00797004 ·Status: COMPLETED
-
Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 COVID-19 (Covid-Smell)
NCT07190911 ·Status: COMPLETED ·Phase: NA
-
Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis
NCT02720653 ·Status: UNKNOWN
-
Acupuncture Therapy for COVID-Related Olfactory Loss
NCT04952389 ·Status: COMPLETED ·Phase: NA
-
Trial Evaluating the Efficacy of Local Budesonide Therapy in the Management of Hyposmia in COVID-19 Patients Without Signs of Severity
NCT04361474 ·Status: COMPLETED ·Phase: PHASE3
-
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
NCT06834477 ·Status: NOT_YET_RECRUITING
-
Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.
NCT06892704 ·Status: RECRUITING
-
Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation
NCT04918953 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction
NCT04406584 ·Status: COMPLETED ·Phase: NA
-
Trial of Directed High-dose Nasal Steroids on Residual Smell Loss in Sinus Patients After Sinus Surgery
NCT01814618 ·Status: WITHDRAWN ·Phase: PHASE2