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The Assessment Of Myocardial Viability Based On CTA/MRI Hybrid Models

NCT04397198 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2022-08-02

No results posted yet for this study

Summary

The aim of HYBRIDHEART study is to develop new imagistic prototype for a complex evaluation of the myocardial viability by superposing computed tomographic angiographic polar maps of the myocardium with magnetic resonance imaging contractile maps in subjects who suffered an acute myocardial infarction. Moreover, the study will evaluate the association of myocardial viability with the level of inflammatory markers and the percent of myocardial fibrosis, also will correlate the imaging-derived parameters with the inflammatory status of the patients, left ventricular function, ischemic time and major adverse cardiovascular events (MACE) rate.

Conditions

  • Acute Myocardial Infarction
  • Myocardial Viability
  • Vulnerable Coronary Plaques
  • Coronary Stenosis
  • Myocardial Fibrosis

Interventions

DIAGNOSTIC_TEST

Speckle Tracking echocardiography

Diagnostic tests: Speckle Tracking echocardiography with analyzing the myocardial strain, myocardial velocities, 128-multislice CCTA with the evaluation of the Calcium Scoring (total and local) , identifying the coronary stenosis, evaluation of the plaque vulnerability degree, assess polar maps of the myocardium. MRI for the evaluation of the percentage of myocardial scar, also the percentage of the viable myocardial tissue using contrast late enhancement sequences, measuring myocardial fibrosis using Q-mass software. Diagnostic tests: Laboratory assessment for the evaluation of the level of hs-CRP and myocardial necrosis biomarkers

Sponsors & Collaborators

  • University of Targu Mures, Romania

    collaborator OTHER

  • Tîrgu Mureș Emergency Clinical County Hospital, Romania

    collaborator OTHER

  • Cardio Med Medical Center

    lead INDUSTRY

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-07-06
Primary Completion
2021-07-06
Completion
2022-06-01

Countries

  • Romania

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04397198 on ClinicalTrials.gov