Impact of Stress CT Myocardial Perfusion on Downstream Resources and Prognosis

Summary

CT myocardial perfusion imaging (CTP) represents one of the newly developed CT-based techniques but its cost-effectiveness in the clinical pathway is undefined. The aim of the study is to evaluate the usefulness of combined evaluation of coronary anatomy and myocardial perfusion in intermediate to high-risk patients for suspected CAD or with known disease in terms of clinical decision-making, resource utilization and outcomes in a broad variety of geographic areas and patient subgroups.

Conditions

• Coronary Artery Disease
• Myocardial Ischemia

Interventions

DIAGNOSTIC_TEST

Integration of CCTA with stress CTP when indicated

When judged indicated, functional assessment with stress CTP perfusion will be performed on top of CCTA.

DIAGNOSTIC_TEST

Standard of care approach

(a) functional non-invasive tests (stress ECG, or imaging-based tests such as Stress Echo, Stress CMR, SPECT or PET) as a gatekeeper for ICA; (b) direct referral to ICA.

Sponsors & Collaborators

• Semmelweis University Heart and Vascular Center

  collaborator OTHER

• Emory University

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

  collaborator OTHER

• Vall d'Hebron Institute Research

  collaborator OTHER

• Humanitas Research Hospital IRCCS, Rozzano-Milan

  collaborator OTHER

• Ospedale Polispecialistico Humanitas Gavazzeni, Bergamo

  collaborator UNKNOWN

• IRCCS San Raffaele

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• Istituto Auxologico Italiano - IRCCS - Ospedale San Luca - Milano

  collaborator UNKNOWN

• A.O.U. Città della Salute e della Scienza - Molinette Hospital

  collaborator OTHER

• Centro Cardiologico Monzino

  lead OTHER

Principal Investigators

• Gianluca Pontone, MD, PhD · Centro Cardiologico Monzino, IRCCS

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-07-01

Primary Completion

2026-06-30

Completion

2027-06-30

Countries

• Italy

Study Locations