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Biomarkers of Acute Kidney Injury Following Cardiac Surgery

NCT04387149 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2020-05-13

No results posted yet for this study

Summary

Acute kidney injury occurs in up to 30% of patients undergoing cardiac surgery. Cardiac surgery associated-acute kidney injury (CSA-AKI) is characterized by a sudden and sustained decrease in renal function with insufficient elimination waste products. The problem is that postoperative diagnosis of CSA-AKI is delayed because it relies solely upon the slow and unreliable rise in serum creatinine (SCr) levels that may lead to delayed start in treatment and increased risk of adverse outcomes. We hypothesize that Matrix Metalloproteins (MMPs) -2, -9 and Neutrophil gelatinase-associated lipocalin (NGAL) are associated with and earlier detectors of CSA-AKI compared to levels of SCr.

Conditions

  • Novel Biomarkers of Acute Kidney Injury Following Cardiac Surgery

Sponsors & Collaborators

  • University of Saskatchewan

    lead OTHER

Principal Investigators

  • Erick D McNair, PhD · University of Saskatchewan

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-06
Primary Completion
2022-01-31
Completion
2022-02-28

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04387149 on ClinicalTrials.gov