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Protein Kinase N1 Level in Patients Undergoing Cardiac Surgery

NCT05386940 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2022-05-23

No results posted yet for this study

Summary

Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Protein kinase N1 (PKN1) is associated with ischemia-reperfusion injury. In this study, relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated.

Conditions

Interventions

OTHER

PKN1 level

different PKN1 level after on-pump cardiac surgery

Sponsors & Collaborators

  • Zhongnan Hospital

    lead OTHER

Principal Investigators

  • ZhiYong Peng · Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-22
Primary Completion
2021-03-14
Completion
2021-03-14

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05386940 on ClinicalTrials.gov