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Role of Delay and Antibiotics on Perforation Rate While Waiting Appendectomy

NCT04378868 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 1800

Last updated 2023-07-11

No results posted yet for this study

Summary

This study evaluates the effects of preoperative delay and antibiotics on perforation rate of appendix while waiting surgery for acute appendicitis. Patients with diagnosed acute appendicitis are randomized into two urgency groups: surgery within 8 hours or surgery within 24 hours. In addition, patients are randomized to either receive antibiotics while waiting or waiting without antibiotics.

Conditions

  • Appendicitis

Interventions

DRUG

Antibiotics, cefuroxime and metronidazole

Patient receives antibiotics while waiting appendectomy

DRUG

No antibiotics

No antibiotics are given while waiting surgery.

OTHER

urgent schedule

Patients can wait up to 8 hours for surgery.

OTHER

less urgent schedule

Patients can wait up to 24 hours for surgery.

Sponsors & Collaborators

  • Helsinki University Central Hospital

    lead OTHER

Principal Investigators

  • Panu J Mentula, MD · Helsinki University Central Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-05-18
Primary Completion
2023-01-23
Completion
2023-02-23

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04378868 on ClinicalTrials.gov