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Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis

NCT00462020 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 102

Last updated 2021-02-21

Study results available
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Summary

The objective of this study is to scientifically evaluate two different management strategies for perforated appendicitis.

The hypothesis is that early discharge with oral antibiotic therapy may result in a dramatic decrease in medical care expenses for the patient.

The primary outcome variable between the two strategies is abscess rate.

Conditions

  • Perforated Appendicitis

Interventions

DRUG

5 days of IV antibiotics (ceftriaxone and metronidazole)

5 days of IV antibiotics (ceftriaxone and metronidazole once a day dosing)

DRUG

Home with oral antibiotics when eating (ampicillin/clavulanic acid)

Augmentin 40mg/kg BID when tolerating POs to complete 7 days total

Sponsors & Collaborators

  • Children's Mercy Hospital Kansas City

    lead OTHER

Principal Investigators

  • Shawn D St. Peter · Children's Mercy Hospital Kansas City

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-03-31
Primary Completion
2008-11-30
Completion
2008-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00462020 on ClinicalTrials.gov