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Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III)

NCT04353804 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2026-03-13

No results posted yet for this study

Summary

Millions of patients survive care in medical and surgical Intensive Care Units (ICUs) every year, only to suffer from a new or accelerated dementia-like process, called post-ICU long-term cognitive impairment (ICU-LTCI). ICU-LTCI causes considerable problems with personal relationships, return to work, and everyday tasks, such as managing medicines and money. No treatment for these patients is currently available. Technology using computerized cognitive rehabilitation could improve ICU-LTCI by harnessing the healing potential of the brain (i.e., neuroplasticity). This intervention is scalable, portable, and economical. The investigators will evaluate the effectiveness of computerized cognitive rehabilitation in a randomized controlled trial of 160 ICU survivors. The investigators hypothesize that this intervention could improve cognition. This research has high potential to influence rehabilitation strategies for Veteran and civilian ICU survivors.

Conditions

  • Cognitive Rehabilitation
  • ICU Survivorship
  • Intensive Care Unit
  • ICU

Interventions

OTHER

Treatment Arm: Computerized Cognitive Rehabilitation

Treatment Arm: Computerized Cognitive Rehabilitation

OTHER

Active Control computer games

Active Control computer games

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    collaborator OTHER

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • E. Wesley Ely, MD MPH · Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

  • Mayur B Patel, MD MPH · Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-03
Primary Completion
2026-07-31
Completion
2027-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04353804 on ClinicalTrials.gov