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Intestinal Permeability, Nutritional Status and Quality of Life in Celiac Disease

NCT04351828 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 44

Last updated 2020-04-21

No results posted yet for this study

Summary

Celiac disease is defined as an autoimmune enteropathy with malabsorption of gluten protein. In recent studies, it has been stated that in individuals diagnosed with celiac disease, intestinal epithelial barrier integrity is impaired. Increased zonulin concentration in blood is considered as an indicator of increased intestinal permeability.

Gluten-free diet is the only treatment of celiac disease. Adherence to gluten free diet provides decreasing of intestinal permeability however gluten free diet has different aspects on nutritional status and health related quality of life in people with celiac disease.

The aim of this study is to determine nutritional status, intestinal permeability and quality of life in people with celiac disease. In the study,it primarily hypothesized that celiac patients noncompliant to gluten-free diet may have increased circulating levels of zonulin and increased intestinal permeability compared to celiac patients compliant to gluten-free diet.

Conditions

Interventions

PROCEDURE

Blood draw once a time

Investigation of intestinal permeability by measuring serum zonulin levels in blood sample

Sponsors & Collaborators

  • Marmara University

    lead OTHER

Principal Investigators

  • Yeşim Öztekin · Marmara University

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-11-05
Primary Completion
2019-04-11
Completion
2019-04-19

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04351828 on ClinicalTrials.gov