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Changes in Intestinal Permeability 4 Hours After Gluten Challenge

NCT03288831 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2019-06-07

No results posted yet for this study

Summary

This study evaluates why people with celiac disease and non-celiac gluten/wheat sensitivity develop rapid onset symptoms within hours of gluten exposure. Half of subjects will be given gluten and half will not.

Conditions

  • Celiac Disease
  • Wheat Hypersensitivity
  • Gluten Sensitivity
  • Gluten Enteropathy
  • Immune System and Related Disorders
  • Duodenal Diseases

Interventions

DIETARY_SUPPLEMENT

Gluten

Six grams of gluten will be mixed with water and Tang flavoring. Subjects will drink the mixture one time.

DIETARY_SUPPLEMENT

Placebo

Subjects will drink a mixture of rice water and Tang flavoring one time.

Sponsors & Collaborators

Principal Investigators

  • Joseph A. Murray, M.D. · Mayo Clinic

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-10-10
Primary Completion
2018-10-30
Completion
2018-10-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03288831 on ClinicalTrials.gov