MedTrace Logo

PRactice of VENTilation in COVID-19 Patients (PRoVENT-COVID)

NCT04346342 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1122

Last updated 2021-07-06

No results posted yet for this study

Summary

The purpose of this national, multicenter service review is to determine and compare ventilation management in COVID-19 patients in the Netherlands, and to determine whether certain ventilation settings have an independent association with duration of ventilation.

In every adult invasively ventilated COVID-19 patient from a participating ICU, granular ventilator settings and parameters will be collected from start of invasive ventilation for up to 72 hours. Follow up is until ICU and hospital discharge, and until day 90. The primary outcome includes main ventilator settings (including tidal volume, airway pressures, oxygen fraction and respiratory rate). Secondary endpoints are ventilator-free days and alive at day 28 (VFD-28); duration of mechanical ventilation; use of prone positioning and recruitment maneuvers; duration of ICU and hospital stay; incidence of kidney injury; and ICU, hospital, 28-day and 90-day mortality.

Conditions

  • COVID
  • Mechanical Ventilation
  • Acute Respiratory Failure

Sponsors & Collaborators

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    lead OTHER

Principal Investigators

  • Marcus Schultz, MD, PhD · Department of Intensive Care, Academic Medical Center, University of Amsterdam

  • Frederique Paulus, PhD · Department of Intensive Care, Academic Medical Center, University of Amsterdam

  • Ary Serpa Neto, MD, PhD · Department of Intensive Care, Academic Medical Center, University of Amsterdam

  • Anna Geke Algera, MD · Department of Intensive Care, Academic Medical Center, University of Amsterdam

  • Anissa Tsonas, MD · Department of Intensive Care, Academic Medical Center, University of Amsterdam

  • Michela Botta, MD · Department of Intensive Care, Academic Medical Center, University of Amsterdam

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-06
Primary Completion
2020-09-01
Completion
2020-09-01

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04346342 on ClinicalTrials.gov