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The Effect of Closed-Loop Versus Conventional Ventilation on Mechanical Power

NCT04827927 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 96

Last updated 2023-08-24

No results posted yet for this study

Summary

Several studies suggest fully-automated ventilation to ventilate with a lower amount of MP in unselected ICU patients, patients after cardiac surgery, and patients with and without ARDS. The current study will directly compare the amount of MP in invasively ventilated critically ill patients by calculating MP breath-by-breath, using the various equations proposed in the literature.

Conditions

  • Mechanical Ventilation
  • Mechanical Power

Interventions

PROCEDURE

Procedure: INTELLiVENT-ASV

With INTELLiVENT-ASV, the patient's conditions, 'ARDS', 'Chronic Hypercapnia' or 'Traumatic Brain Injury' can be chosen, if applicable. The controllers for minute volume, PEEP and FiO2 are all activated, and the target shifts for etCO2 and SpO2 are adjusted, if necessary.

PROCEDURE

Procedure: Conventional ventilation

With conventional ventilation, the same etCO2 and SpO2 levels are targeted as with INTELLiVENT-ASV, but here the caregiver is fully responsible for choosing the settings.

Sponsors & Collaborators

  • Reinier de Graaf Groep

    collaborator OTHER

  • Dijklander Ziekenhuis

    collaborator OTHER

  • University of Zurich

    collaborator OTHER

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    lead OTHER

Principal Investigators

  • Marcus J Schultz, MD, PhD · Department of Intensive Care, Amsterdam University Medical Centre - location AMC

  • Frederique Paulus, PhD · Department of Intensive Care, Amsterdam University Medical Centre - location AMC

  • Laura A Buiteman-Kruizinga, RN, BSc · Department of Intensive Care, Amsterdam University Medical Centre - location AMC

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-05
Primary Completion
2023-04-01
Completion
2023-07-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04827927 on ClinicalTrials.gov