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The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia

NCT04325685 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2023-11-08

No results posted yet for this study

Summary

Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization. The research team is considering that oropharyngeal decontamination with bacteriophages can prevent the developing of the ventilator - associated pneumoniae. There will be three groups in this investigation: placebo, antiseptic drug (Octenisept) and bacteriophage (Sexthaphag).

Conditions

Interventions

DRUG

Control

Oropharyngeal decontamination with saline will be performing three time a day every 8 hours during mechanical ventilation

DRUG

Antiseptic Solution

Oropharyngeal decontamination with antiseptic solution will be performing three time a day every 8 hours during mechanical ventilation

DRUG

Bacteriophage

Oropharyngeal decontamination with bacteriophage will be performing three time a day every 8 hours during mechanical ventilation

Sponsors & Collaborators

  • Northern State Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-01
Primary Completion
2021-12-31
Completion
2023-11-07

Countries

  • Russia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04325685 on ClinicalTrials.gov