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Immune Suppression and Ventilator Associated Pneumonias

NCT01135277 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-09-11

No results posted yet for this study

Summary

Patients in the ICU are already predisposed to nosocomial infections, which are both costly and potentially life threatening, and it appears that the immune paralysis of sepsis may put these patients at greater risk for secondary infections, though this has not been proven conclusively. One measure of this sepsis-induced immune suppression is monocyte deactivation. The investigators hypothesize that, as a cornerstone of the monocytic innate immune response to infection, the inflammasome is critical to monocyte function during sepsis.

Conditions

Sponsors & Collaborators

  • Matthew Exline

    lead OTHER

Principal Investigators

  • Matthew Exline, M.D. · Ohio State University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2012-11-30
Completion
2012-11-30

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01135277 on ClinicalTrials.gov