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Can we Better Understand the Development of VAP and Eventually Predict and Prevent it?

NCT01875692 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 286

Last updated 2014-12-03

No results posted yet for this study

Summary

Pathogens of ventilator-associated pneumonia (VAP) come from colonizers of the trachea. The hypothesis of the investigators is that during the first days of intubation, independently of the use of antibiotics, there is a change in the oro-pharyngeal flora leading to the selection of one pathogen in the trachea, that will finally be the cause of VAP.

The investigators designed a prospective study including 300 patients intubated for more than 3 days, with daily analysis of oro-pharyngeal juice and tracheal aspirate by culture and metagenomics, in order to determine if this microbiological surveillance permits:

1. To predict a high risk to develop a VAP in the next 48h and even to predict its agent
2. To better understand the development of VAP by studying the evolution of the "respiratory flora" in the context of intubation

Conditions

  • Pneumonia, Ventilator-Associated

Sponsors & Collaborators

  • University Hospital, Geneva

    lead OTHER

Principal Investigators

  • Jacques Schrenzel, Prof. · University Hospital, Geneva

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2014-03-31
Completion
2014-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01875692 on ClinicalTrials.gov