PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents

Summary

PATH (Promoting AdolescenT Health) 2 Purpose is a two-arm comparative effectiveness research trial to that will evaluate the ability of the interventions, Competent Adulthood Transition with Cognitive-behavioral \& Interpersonal Training (CATCH-IT) and Teens Achieving Mastery over Stress (TEAMS), to intervene early to prevent depressive illness and potentially other common mental health disorders. Using cluster randomization, 564 participants eligible for the study will be offered one of two different depression prevention programs in multiple sites in Chicagoland, Rockford, Illinois; Dixon, Illinois; and Louisville, Kentucky. In response to the Coronavirus Disease 2019 (COVID-19) pandemic, we will employ a public health media campaign to recruit a second cohort of 100 adolescents state-wide in Illinois, Kentucky, and Massachusetts individually randomized to either intervention. The study will also assess teens', parents' and providers' experiences with each intervention approach. Finally, we will examine the impact of the COVID-19 pandemic on adolescents at-risk for depression who are enrolled in our study.

Conditions

• Depression

Interventions

BEHAVIORAL

CATCH-IT

Competent Adulthood Transition with Cognitive-behavioral \& Interpersonal Training (CATCH-IT) is an internet-based depression prevention program that targets decreasing modifiable risk factors while enhancing protective factors in at-risk adolescents, and that includes a parent program. It has been shown to be safe, feasible, and efficacious.

BEHAVIORAL

TEAMS

Teens Achieving Mastery over Stress (TEAMS) is an 8-session group depression prevention program teaching teens how to deal with stress and negative moods, and ways to manage low mood based on cognitive behavioral therapy (CBT) principles and strategies. Efficacy has been demonstrated by several trials over time.

Sponsors & Collaborators

• University of Illinois College of Medicine Rockford

  collaborator OTHER

• Wake Forest University Health Sciences

  collaborator OTHER

• Katherine Shaw Bethea Hospital

  collaborator UNKNOWN

• University of Louisville

  collaborator OTHER

• Patient-Centered Outcomes Research Institute

  collaborator OTHER

• Brown University

  collaborator OTHER

• Mile Square Health Center

  collaborator OTHER

• University of Illinois at Chicago

  lead OTHER

Principal Investigators

• Benjamin W Van Voorhees, MD, MPH · University of Illinois at Chicago, School of Medicine

• Tracy RG Gladstone, PhD · Wellesley College, Wellesley Centers for Women

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

13 Years

Max Age

19 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-01-01

Primary Completion

2026-07-01

Completion

2026-10-01

Countries

• United States

Study Locations