The PATHway Study: Primary Care Based Depression Prevention in Adolescents

Summary

Prevention of depressive disorders has become a key priority for the NIMH, but the investigators have no widely available public health strategy to reduce morbidity and mortality. To address this need, the investigators developed and evaluated the primary care based-technology "behavioral vaccine," Competent Adulthood Transition with Cognitive-Behavioral Humanistic and Interpersonal Therapy (CATCH-IT). The investigators will engage N=4 health systems representative of the United States health care system, and conduct a factorial design study to optimize the intervention in preparation for an implementation study and eventual dissemination.

Conditions

• Depression
• Mental Disorder in Adolescence

Interventions

BEHAVIORAL

Competent Adulthood Transition with Cognitive-Behavioral, Humanistic and Interpersonal Training

Self-directed, technology-based, depression prevention program for adolescents and parents.

Sponsors & Collaborators

• Wake Forest University Health Sciences

  collaborator OTHER

• Endeavor Health

  collaborator OTHER

• University of Chicago

  collaborator OTHER

• National Institute of Mental Health (NIMH)

  collaborator NIH

• Mile Square Health Center

  collaborator OTHER

• Lawndale Christian Health Center

  collaborator OTHER

• Ann & Robert H Lurie Children's Hospital of Chicago

  collaborator OTHER

• University of Illinois at Chicago

  lead OTHER

Principal Investigators

• Benjamin W Van Voorhees, MD, MPH · UIC, College of Medicine

• Tracy RG Gladstone, PhD · Wellesley College

• Calvin Rusiewski, MBBS · UIC, College of Medicine

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

13 Years

Max Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-02-01

Primary Completion

2024-10-31

Completion

2026-10-31

Countries

• United States

Study Locations