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Deciphering AMD by Deep Phenotyping and Machine Learning- Prospective Study - PINNACLE

NCT04269304 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 429

Last updated 2024-11-12

No results posted yet for this study

Summary

We will conduct a prospective non-interventional study including 400 early AMD patients (=600 untreated early AMD eyes, including both unilateral (AREDS IV) and bilateral (≥AREDS II)) over a minimum of 1 year to specifically investigate the morphological sequence of events preceding the conversion towards late AMD. All patients will be followed by Optical Coherence Tomography (OCT) imaging every 4 months to detect the earliest focal sites of disease progression. As soon as focal areas of change are observed by the Vienna Reading Center (VRC), a targeted follow-up schedule will be triggered to investigate the events at that area of change in a targeted manner.

Conditions

  • Age-related Macular Degeneration

Sponsors & Collaborators

  • Imperial College London

    collaborator OTHER

  • University of Basel

    collaborator OTHER

  • Medical University of Vienna

    collaborator OTHER

  • University of Michigan

    collaborator OTHER

  • King's College London

    collaborator OTHER

  • University College, London

    collaborator OTHER

  • University of Southampton

    lead OTHER

Principal Investigators

  • Andrew J Lotery, Prof · University of Southampton

Eligibility

Min Age
55 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-10-28
Primary Completion
2025-06-30
Completion
2025-06-30

Countries

  • Austria
  • Switzerland
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04269304 on ClinicalTrials.gov