Autoimmunity And Immune Deficiency After Spinal Cord Injury: Association With Rehabilitation Outcomes

Summary

The SCIentinel-prolong study systematically analyzes humoral autoantibody responses and thier interaction with post-spinal cord injury (SCI) immune-deficiency and infections as well as their association with the clinical course of rehabilitation. Therefore, molecular and immunological tests in blood and cerebrospinal fluid specimen are combined with clinical outcomes ranging from neurological function, neuropathic pain and spasticity to walking tests and measures of independence in daily living within the first year after SCI. Including a control group with participants suffering from vertebral fractures without SCI allows to differentiate between neurological and general injury and treatment effects.

Conditions

• Spinal Cord Trauma

Sponsors & Collaborators

• Foundation Wings For Life

  collaborator OTHER

• University Hospital Tuebingen

  collaborator OTHER

• Unfallkrankenhaus Berlin

  collaborator OTHER

• Balgrist University Hospital

  collaborator OTHER

• I.R.C.C.S. Fondazione Santa Lucia

  collaborator OTHER

• University of Zurich

  collaborator OTHER

• Medical University of Vienna

  collaborator OTHER

• Ruhr University of Bochum

  collaborator OTHER

• Swiss Federal Institute of Technology

  collaborator OTHER

• King's College London

  collaborator OTHER

• McGill University Health Centre/Research Institute of the McGill University Health Centre

  collaborator OTHER

• Ohio State University

  collaborator OTHER

• Marcel Kopp, MD

  lead OTHER

Principal Investigators

• Jan M Schwab, MD, PhD · Ohio State University

• Marcel A Kopp, MD · Charite University, Berlin, Germany

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-10-31

Primary Completion

2025-10-31

Completion

2026-04-30