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Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury

NCT05681936 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 225

Last updated 2025-12-15

No results posted yet for this study

Summary

Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the motor and sensory neurons. Alterations in the activity pattern will reveal the effect upon task-related spinal cord activity of the lower motor neurons and sensory neurons undergoing trauma-induced neurodegeneration, at a spatial specificity that has not been possible so far. Results of this study will be of crucial importance because SCI patients can only profit from regeneration-inducing therapies if spinal neuronal function is preserved below the level of lesion.

Conditions

  • Spinal Cord Injuries
  • Neurogenic Bladder Dysfunction
  • Degenerative Cervical Spinal Stenosis

Sponsors & Collaborators

  • Swiss National Science Foundation

    collaborator OTHER

  • Swiss Paraplegic Research, Nottwil

    collaborator NETWORK

  • University of Zurich

    lead OTHER

Principal Investigators

  • Patrick Freund, Prof. Dr. med. Dr. rer. nat. · University of Zurich

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2027-08-31
Completion
2027-08-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05681936 on ClinicalTrials.gov