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Renal Perfusion and the Development of AKI Following Traumatic Injury

NCT06917053 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2025-04-08

No results posted yet for this study

Summary

Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.

Conditions

  • Traumatic Haemorrhagic Shock
  • AKI (Acute Kidney Injury) Due to Trauma
  • AKI - Acute Kidney Injury

Interventions

DEVICE

Ultrasound (including contrast enhanced ultrasound)

Ultrasound measures: contrast enhanced ultrasound (CEUS) of the kidney, venous excess ultrasound (VExUS), echocardiography

DEVICE

Sublingual incident dark field videomicroscopy

Sublingual incident dark field (IDF) videomicroscopy

DEVICE

Urinary oxygen tension.

Continuous urinary oxygen tension

Sponsors & Collaborators

  • King's College Hospital NHS Trust

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-13
Primary Completion
2026-01-31
Completion
2026-07-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06917053 on ClinicalTrials.gov