Evaluating the Acute Glycemic Response to Different Strategies of Breaking Up Sedentary Time

Summary

This study aims to determine the most effective strategy of reducing sedentary behavior to improve health. Specifically, we aim to answer the following questions: (a) To determine if there is a significant difference in acute post-prandial glucose response between continuous sitting and two intermittent standing regimes (high frequency, low duration breaks (HFLD) and low frequency, high duration breaks (LFHD)). We hypothesize that intermittent standing (combined HFLD breaks and LFHD breaks regimes) will result in lower overall acute post-prandial glucose compared to continuous sitting. (b) To determine if there is a significant difference in acute post-prandial glucose response between two strategies to reduce sitting with standing (HFLD standing breaks vs. LFHD standing breaks). We hypothesize that the HFLD breaks condition will elicit lower acute post-prandial glucose level compared to the LFHD breaks condition. All eligible participants will be consented and subjected to all three study conditions: (i) Uninterrupted sitting, (ii) HFLD breaks, and (iii) LFHD breaks. The order at which participants were subjected to these conditions will be randomly determined and each condition were performed a week apart. Standardized meals (breakfast and lunch) will be provided during each lab visit and participants will be then be asked to perform their usual work activity using a sit-stand workstation in the lab. Depending on their assigned condition, the participants will be prompted to stand or sit for a given period of time. A continuous glucose monitor will be used to measure glucose response to the intervention while an activPAL device will be used to make sure that participants are compliant with the study protocol.

Conditions

• Pre Diabetes
• Postprandial Hyperglycemia

Interventions

BEHAVIORAL

CS: Continuous sitting

Participants were asked to sit continuously throughout the duration of the lab visit.

BEHAVIORAL

HFLD: HIgh frequency, low duration standing breaks

Participants were asked to interrupt their sitting time every 15 minutes using 2.5-minute standing breaks.

BEHAVIORAL

LFHD: Low frequency, high duration standing breaks

Participants were asked to interrupt their sitting time every 60 minutes using 10-minute standing breaks.

Sponsors & Collaborators

• Arizona State University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

35 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-08-01

Primary Completion

2019-06-14

Completion

2019-06-14

Countries

• United States

Study Locations