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The Effects of Two Days of Bedrest on Insulin Resistance in Type 2 Diabetics

NCT00508599 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2024-03-12

No results posted yet for this study

Summary

The hypothesis of this study is that bed rest in diabetic patients will result in a deterioration of metabolic control (primarily glucose).

Specific aims:

1. To determine the change in metabolic control in type 2 diabetic individuals when three days of bed rest is compared to three days of activity;
2. To determine the rate of progression of the deterioration in metabolic control and the magnitude of the decrease;
3. To assess whether the anticipated deterioration of metabolic control has effects on several parameters of glucose metabolism, including hyperglycemia and hypoglycemia;
4. To determine the effects of bed rest on surrogate markers of atherosclerosis, such as plasminogen activator inhibitor 1 (PAI1), C-reactive protein (CRP), and homocysteine.
5. To compare the effects of 48 hours of bed rest on orthostatic responses in type 2 diabetic patients, and healthy non-diabetics.
6. To make recommendations to the diabetic community to prevent metabolic deterioration during a 3 day hospitalization.

Conditions

Interventions

OTHER

Study 2 (48 hours of complete bed rest)

Effects of 48 hours of bed rest on insulin resistance in type 2 diabetic subjects.

Sponsors & Collaborators

  • University of New Mexico

    lead OTHER

Principal Investigators

  • David S Schade, M.D. · University of New Mexico

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-01-31
Primary Completion
2004-01-31
Completion
2006-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00508599 on ClinicalTrials.gov