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Efficacy of Antiresorptive and Bone Forming Material on Dental Implants

NCT04140006 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2019-10-25

No results posted yet for this study

Summary

Insertion of a metal implant is considered one of the most common surgeries for fracture treatment, joint replacement, and dental implants. The success rate of these implants depends on their fixation which is in turn related primarily on the strength of the bone holding them. Studies evaluating the influence of local application of antiresorptive drugs, like bisphosphonates, on implanted endoprostheses whether orthopedic or dental is increasing annually with more and more experimental studies as well as clinical trials worldwide. On the other hand implants that release medications that enhance bone formation will lead to improved implant fixation and success. The objective of this study was to evaluate the effect of topical application of alendronate sodium gel and recombinant human bone morphogenic protein 2 on dental implant stability and crestal bone level.

Conditions

  • Partial Edentulism

Interventions

DRUG

ALN Gel

Flapped surgery for insertion of dental implant with topical application of ALN gel

DRUG

BMP Gel

Flapped surgery for insertion of dental implant with topical application of BMP gel

DRUG

Mixed Gel

Flapped surgery for insertion of dental implant with topical application of mixed gel of ALN and BMP

DRUG

Control

Flapped surgery for insertion of dental implant without topical application of any gel

Sponsors & Collaborators

  • University of Baghdad

    lead OTHER

Principal Investigators

  • Salwan Y Bede · University of Baghdad

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-07-01
Primary Completion
2020-07-01
Completion
2020-07-01

Countries

  • Iraq

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04140006 on ClinicalTrials.gov