Effectiveness of ALB-PRF With Two Types of Bone Grafts With Putty Form Around Immediate Dental Implants.

Summary

The goals of this clinical trial study is to evaluate the additive effect, of using ALB-PRF membrane combined with two different types of bone grafts with putty form in treatment of peri-implant bony defects around immediate dental implant within the maxillary esthetic zone.

Researchers will compare the ALB- PRF membrane extracted from patient blood with synthetic collagen membrane in addition to the putty form bone graft The main questions it aims to answer are:

Is the ALB-PRF is considered suitable alternative to synthetic collagen membrane in GBR techniques? also, growth factors releasing form ALB-PRF can continue over 21 days.

Participants will:

receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and collagen as membrane. Also, in other hand participant will receive immediate implant with beta-tricalcium phosphate + calcium sulphate as bone graft and collagen as membrane. and compered with participants receive the same bone and implant technique except for ALB-PRF membrane instead of collagen.

Conditions

• Dental Implants
• Immediate Implant Soft Tissue Healing
• Immediate Implant With Bone Graft

Interventions

PROCEDURE

participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and collagen membrane.

1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000). 2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol. 3. Sulcular incision with be made 15c blade . 4. Implant placement with copious irrigation. 5. Membranes placement: collagen followed by insertion of nano-crystalline putty hydroxyapatite. 6. Customized healing abutment application. 7. Suturing of wound edges with 0.5 suture around the customized healing abutment.

PROCEDURE

participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and ALB- PRF as membrane.

1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000). 2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol. 3. Sulcular incision with be made 15c blade without vertical releasing incision. 4. Implant placement with copious irrigation. 5. Membranes placement: ALB-PRF followed by insertion of nano-crystalline putty hydroxyapatite.. 6. Customized healing abutment application. 7. Suturing of wound edges with 0.5 suture around the customized healing abutment.

PROCEDURE

participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and collagen membrane.

1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000). 2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol. 3. Sulcular incision with be made 15c blade . 4. Implant placement with copious irrigation. 5. Membranes placement: collagen followed by insertion of eta-tricalcium phosphate + calcium sulphate bone graft. 6. Customized healing abutment application. 7. Suturing of wound edges with 0.5 suture around the customized healing abutment.

PROCEDURE

participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and ALB-PRF membrane.

1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000). 2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol. 3. Sulcular incision with be made 15c blade . 4. Implant placement with copious irrigation. 5. Membranes placement: ALB-PRF followed by insertion of eta-tricalcium phosphate + calcium sulphate bone graft. 6. Customized healing abutment application. 7. Suturing of wound edges with 0.5 suture around the customized healing

Sponsors & Collaborators

• Mansoura University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-08-14

Primary Completion

2025-04-01

Completion

2025-06-01

Countries

• Egypt

Study Locations