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Effect of Gene Polymorphisms on the Pathogenesis of Cancer Cachexia

NCT04131478 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2019-11-12

No results posted yet for this study

Summary

Cachexia not only directly increases the morbidity and mortality, it also aggravates the side effects of chemotherapy and reduces the overall quality of life that is often considered the major and direct cause of morbidity of a large proportion (\>40%) of cancer patients. Individuals with upper gastrointestinal tumors have the highest rate of developing cachexia associated complications. Chemical and physical signals render an environment conducive for disuse and untenable for proper muscle function leading to wasting.

Till now, several functional single-nucleotide polymorphisms (SNPs) within TNF-α gene have been identified and described as cancer related genetic alterations.

Conditions

  • Cancer Cachexia

Interventions

GENETIC

Pharmacogenetic testing

Pharmacogenetic testing for TNF alfa

Sponsors & Collaborators

  • Misr International University

    collaborator OTHER

  • Ain Shams University

    collaborator OTHER

  • Cairo University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-06-20
Primary Completion
2020-06-20
Completion
2021-01-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04131478 on ClinicalTrials.gov