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Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy

NCT04096651 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2019-09-20

No results posted yet for this study

Summary

The main hypothesis is that the gait and postural deficits in the Caribbean form of PSP may be associated with a dysfunction of the cerebral cortex, as they result from sub-cortical involvement in classical forms. The investigators will characterize the gait and posture with a force platform to collect biomechanical gait parameters, coupled with the kinematic and electromyographic (EMG) study. Then the investigators realize a multimodal imaging study \[structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI)\] that allow us to determine if a correlation can be found between the clinical characteristics of postural control and walking on one hand, and morphological changes and structural MRI changes in cortico-subcortical pathways on the other hand. The study of performance on neuropsychological tests, registration of ocular movements and the analysis of functional cortical activity will complete our multimodal approach. A better understanding of these disorders is expected to propose new drug treatment and rehabilitative strategies.

Conditions

Interventions

OTHER

gait recordings

gait recordings

OTHER

brain magnetic resonance imaging

brain magnetic resonance imaging

OTHER

oculomotor movement recordings

oculomotor movement recordings

Sponsors & Collaborators

  • University Hospital Center of Martinique

    collaborator OTHER

  • Groupe Hospitalier Pitie-Salpetriere

    collaborator OTHER

  • Centre Hospitalier Universitaire de la Guadeloupe

    lead OTHER

Principal Investigators

  • Annie LANNUZEL, PU-PH · University Hospital of Guadeloupe

  • Régine EDRAGAS, PH · University Hospital of Martinique

  • Marie-Laure WELTER, PU-PH · Groupe Hospitalier Pitie-Salpetriere

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-09-28
Primary Completion
2018-07-12
Completion
2018-07-12

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04096651 on ClinicalTrials.gov